He had his right thumb and lower hand/wrist area taped by a trainer on the bench and remained on the sideline for the rest of the game in uniform.
After the game, Brees acknowledged that he was “concerned” about the severity of the injury.
Bridgewater finished the game for Brees, going 17-of-30 for 165 yards in a 27-9 loss to the Rams. It was only the third time in the Sean Payton era that the Saints failed to score a touchdown.
Brees, 40, has missed only one start because of injury since high school — when he was ruled out of a Week 3 game at Carolina in 2015 with a shoulder injury.
Caesars Sportsbook had the Saints at 8-1 to win the Super Bowl before the Rams game. New Orleans is now 25-1 after news that Brees could be out for six weeks.